Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piroctone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 18/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piroctone SCHEMBL4728215 | 1.00 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL2843 | 1.00 | KDM4E (0.44) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL457354 | 0.99 | KDM4E (0.43) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL20598939 | 0.94 | KDM4E (0.40) | KDM4ELMNATP53CYP1A2ALOX12 | |
| Piroctone SCHEMBL30969893 | 0.92 | IDH1 (0.48) | IDH1 | |
| Piroctone SCHEMBL3588 | 0.92 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL7568492 | 0.92 | IDH1 (0.50) | IDH1 | |
| Piroctone SCHEMBL28331516 | 0.91 | IDH1 (0.47) | IDH1 | |
| Piroctone SCHEMBL10357073 | 0.91 | IDH1 (0.49) | IDH1 | |
| Piroctone SCHEMBL1289257 | 0.91 | IDH1 (0.49) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102552056-B | Shampoo composition | NICE GROUP CO LTD | 2013-06-12 | — | — | CN | claimed |
| CN-102552056-A | Shampoo composition | NICE GROUP CO LTD | 2012-07-11 | — | — | CN | claimed |
| EP-3802494-A1 | PROCESS FOR FORMING 2-HYDROXYPYRIDINE-1-OXIDE OR DERIVATIVES THEREOF | Clariant International Ltd (CH) | 2021-04-14 | — | — | EP | disclosed |
| EP-3427583-B1 | COMPOSITION COMPRISING SORBITAN MONOCAPRYLATE AND PIROCTONE OLAMINE | CLARIANT INT LTD (CH) | 2020-02-19 | — | — | EP | disclosed |
| EP-3427583-A1 | COMPOSITION COMPRISING SORBITAN MONOCAPRYLATE AND PIROCTONE OLAMINE | Clariant International Ltd (CH) | 2019-01-16 | — | — | EP | disclosed |
| EP-2432316-B1 | COMPOSITION CONTAINING SORBITAN MONOCAPRYLATE AND ANTIMICROBIAL SUBSTANCES | CLARIANT INT LTD (CH) | 2018-09-12 | — | — | EP | disclosed |
| CN-106232085-A | Microcapsules containing colorants | 塔格拉生物技术有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-105163706-A | Microcapsules comprising sunscreen agents | TAGRA BIOTECHNOLOGIES LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-104983596-A | Silicone oil free mild conditioning shampoo composition and preparation method thereof | GUANGZHOU BAFEORII CHEMICAL CO LTD | 2015-10-21 | — | — | CN | disclosed |
| US-8969390-B2 | Composition containing sorbitan monocaprylate and antimicrobial substances | CLARIANT FINANCE (BVI) LIMITED (VG) | 2015-03-03 | — | — | US | disclosed |
| EP-2809649-A1 | POLYGLYCOL-ETHER-FREE SULFOSUCCINATES BASED ON POLYGLYCERIN PARTIAL ESTERS AND USE THEREOF | Evonik Industries AG (DE) | 2014-12-10 | — | — | EP | disclosed |
| EP-2797571-A2 | AQUEOUS HAIR AND SKIN CLEANING COMPOSITIONS COMPRISING BIOTENSIDES | Evonik Industries AG (DE) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013113536-A1 | POLYGLYCOL-ETHER-FREE SULFOSUCCINATES BASED ON POLYGLYCERIN PARTIAL ESTERS AND USE THEREOF | EVONIK INDUSTRIES AG (DE) | 2013-08-08 | — | — | WO | disclosed |
| WO-2013098066-A2 | AQUEOUS HAIR AND SKIN CLEANING COMPOSITIONS COMPRISING BIOTENSIDES | EVONIK INDUSTRIES AG (DE) | 2013-07-04 | — | — | WO | disclosed |
| CN-102552056-B | Shampoo composition | NICE GROUP CO LTD | 2013-06-12 | — | — | CN | disclosed |
| CN-102552056-A | Shampoo composition | NICE GROUP CO LTD | 2012-07-11 | — | — | CN | disclosed |
| US-20120101135-A1 | COMPOSITION CONTAINING SORBITAN MONOCAPRYLATE AND ANTIMICROBIAL SUBSTANCES | CLARIANT FINANCE (BVI) LIMITED (VG) | 2012-04-26 | — | — | US | disclosed |
| US-20080014166-A1 | Cosmetic or pharmaceutical compositions comprising modified polyorganosiloxanes | CLARIANT INTERNATIONAL, LTD. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080014166-A1 | Cosmetic or pharmaceutical compositions comprising modified polyorganosiloxanes | POLR1C, F12, MSR1 | KDM4E 3398/4885LMNA 1447/4885TP53 2514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.