Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2842326 | 0.92 | MC4R (0.48) | MC4RTSHR | |
| SCHEMBL2843679 | 0.91 | MC4R (0.52) | MC4RTSHRALDH1A1GLAGAA | |
| SCHEMBL2837619 | 0.82 | ALDH1A1 (0.48) | MC4RTSHRALDH1A1GLAGAA | |
| SCHEMBL2836197 | 0.81 | MC4R (0.53) | MC4RTSHRALDH1A1GAAL3MBTL1 | |
| SCHEMBL2845584 | 0.80 | ALDH1A1 (0.48) | MC4RTSHRALDH1A1GLAGAA | |
| SCHEMBL2844709 | 0.79 | MC4R (0.66) | MC4RTSHRALDH1A1GAAL3MBTL1 | |
| SCHEMBL13381708 | 0.79 | ALDH1A1 (0.49) | TSHRALDH1A1GAAL3MBTL1 | |
| SCHEMBL13381944 | 0.79 | MC4R (0.50) | MC4RTSHRL3MBTL1MAPT | |
| SCHEMBL2842779 | 0.78 | L3MBTL1 (0.51) | MC4RTSHRALDH1A1GAAL3MBTL1 | |
| SCHEMBL2843950 | 0.77 | MC4R (0.53) | MC4RTSHRALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |