Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BID | P55957 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431745 | 0.93 | ATM (0.58) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL27454865 | 0.84 | ATM (0.49) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL27593823 | 0.83 | ATM (0.45) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL3566598 | 0.77 | PGR (0.50) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL30015910 | 0.76 | ATM (0.59) | ATMKAT6ABRD4HSD17B2MC4R | |
| SCHEMBL29134888 | 0.76 | ATM (0.59) | ATMKAT6ABRD4HSD17B2MC4R | |
| SCHEMBL11962953 | 0.74 | CA1 (0.59) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL21872155 | 0.73 | ATM (0.73) | ATMKAT6ABRD4EGFRERBB2 | |
| SCHEMBL1684516 | 0.72 | FLT1 (0.56) | ATMKAT6ABRD4FLT1FLT4 | |
| SCHEMBL2069136 | 0.72 | ATM (0.48) | ATMKAT6ABRD4FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087338-B | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2021-03-02 | — | — | CN | claimed |
| CN-111087338-A | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2020-05-01 | — | — | CN | claimed |
| CN-111087338-B | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-111087338-A | Sulfonamide-substituted pyrrolidones derivative and preparation method thereof | 常州大学 | 2020-05-01 | — | — | CN | disclosed |