Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.35 |
| ▸ | TUBB | P07437 | 2/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026494 | 0.80 | CYP3A4 (0.48) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL12918510 | 0.73 | CYP3A4 (0.43) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL27961165 | 0.72 | TSHR (0.49) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL20154101 | 0.70 | PIK3CA (0.53) | ALDH1A1KDM4EPIK3CAMTORLMNA | |
| SCHEMBL31205699 | 0.68 | RPS6KA5 (0.52) | ALDH1A1KMT2ACYP3A4CYP2E1CYP2A6 | |
| SCHEMBL28728263 | 0.67 | CYP3A4 (0.48) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL2666367 | 0.67 | CYP3A4 (0.44) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL19764720 | 0.66 | MAOA (0.53) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL12342913 | 0.66 | CYP3A4 (0.47) | ALDH1A1KDM4ECYP3A4CYP2E1CYP2A6 | |
| SCHEMBL19211560 | 0.64 | KDR (0.52) | ALDH1A1CYP3A4CYP2E1CYP2A6TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423417-B | Substituted reverse pyrimidine Bmi-1 inhibitors | PTC医疗公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-111423417-A | Substituted reverse pyrimidine Bmi-1 inhibitors | PTC医疗公司 | 2020-07-17 | — | — | CN | disclosed |