Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154103 | 0.82 | MTOR (0.49) | PIK3CAMTOR | |
| SCHEMBL4018233 | 0.81 | PIK3CA (0.65) | PIK3CAMTORNPSR1MAPK1LMNA | |
| SCHEMBL20154108 | 0.77 | KMT2A (0.43) | PIK3CAMTORNPSR1ALDH1A1MAPK1 | |
| SCHEMBL20154109 | 0.72 | NPSR1 (0.49) | NPSR1KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL8012871 | 0.72 | PIK3CA (0.79) | PIK3CAMTORNPSR1ALDH1A1PDE10A | |
| SCHEMBL10904452 | 0.71 | ALDH1A1 (0.53) | PIK3CAMTORKDM4EALDH1A1MAPK1 | |
| SCHEMBL1311534 | 0.71 | PIK3CA (0.61) | PIK3CAMTORNPSR1PIK3R1 | |
| SCHEMBL28435645 | 0.70 | ALDH1A1 (0.39) | PIK3CAMTORKDM4EALDH1A1LMNA | |
| SCHEMBL16036853 | 0.69 | PIK3R1 (0.48) | PIK3CANPSR1KDM4EALDH1A1MAPK1 | |
| SCHEMBL8008565 | 0.69 | PIK3CA (1.00) | PIK3CAMTORPIK3R1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538523-B1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018087527-A1 | PYRIMIDINONE DERIVATIVES AS CDC7 INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-05-17 | — | — | WO | disclosed |