Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22407332 | 0.99 | ENPP3 (0.50) | ENPP3ENPP1KDM4EHTTALDH1A1 | |
| SCHEMBL22407561 | 0.90 | ENPP3 (0.47) | ENPP3ENPP1EGFRMET | |
| SCHEMBL22407611 | 0.84 | ENPP1 (0.48) | ENPP1SRCMETTGFBR1 | |
| SCHEMBL20782642 | 0.84 | ENPP3 (0.51) | ENPP3ENPP1KDM4EHTTALDH1A1 | |
| SCHEMBL20770889 | 0.84 | ENPP3 (0.69) | ENPP3ENPP1HTTEGFRGAK | |
| Hydrochloric Acid SCHEMBL20770994 | 0.83 | ENPP3 (0.50) | ENPP3ENPP1KDM4EHTTALDH1A1 | |
| SCHEMBL22407557 | 0.83 | ENPP3 (0.48) | ENPP3ENPP1EGFRMET | |
| SCHEMBL20782644 | 0.82 | PDGFRB (0.46) | ENPP3ENPP1EGFRLCKSRC | |
| SCHEMBL22407529 | 0.82 | FLT3 (0.42) | KMT2AMETPDGFRA | |
| SCHEMBL20775108 | 0.81 | MET (0.50) | ENPP3ENPP1KDM4EHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111315723-A | Extramembranous nucleotide pyrophosphatase-phosphodiesterase 1(ENPP-1) inhibitor and application thereof | 艾伯维公司 | 2020-06-19 | — | — | CN | disclosed |