Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.46 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28210913 | 1.00 | HDAC1 (0.52) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Succinic Acid SCHEMBL4667877 | 1.00 | HDAC1 (0.52) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Succinic Acid SCHEMBL28276766 | 0.93 | HDAC1 (0.46) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Adipic Acid SCHEMBL27696357 | 0.93 | FFAR4 (0.59) | FFAR4FFAR1LMNAALDH1A1TDP1 | |
| Butyric Acid SCHEMBL27916950 | 0.92 | HDAC1 (0.65) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Succinic Acid SCHEMBL28829567 | 0.91 | TP53 (0.48) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Levulinic Acid SCHEMBL28753020 | 0.91 | LMNA (0.61) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Adipic Acid SCHEMBL437561 | 0.91 | FFAR4 (0.57) | FFAR4FFAR1ALDH1A1TDP1AKR1B1 | |
| Succinic Acid SCHEMBL28210832 | 0.91 | HDAC1 (0.44) | HDAC1HDAC2FFAR3HDAC3HDAC8 | |
| Glutarate SCHEMBL8153856 | 0.90 | FFAR4 (0.55) | HDAC1HDAC2FFAR3HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113980252-A | Continuous production method of modified poly (butylene succinate) | 上海师范大学 | 2022-01-28 | — | — | CN | claimed |
| CN-115975983-A | Application of alkali-resistant broad-spectrum plastic degrading enzyme | 北京理工大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-115558090-A | Preparation method of poly (butylene succinate) with low tetrahydrofuran content | 中国天辰工程有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-114634717-A | Plant fiber-based biodegradable tableware and preparation method thereof | 河北工程大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-113234214-B | Copolyester and preparation method thereof | 中国科学院大连化学物理研究所 | 2022-02-15 | — | — | CN | disclosed |
| CN-113980252-A | Continuous production method of modified poly (butylene succinate) | 上海师范大学 | 2022-01-28 | — | — | CN | disclosed |
| CN-113234214-A | Copolyester and preparation method thereof | 中国科学院大连化学物理研究所 | 2021-08-10 | — | — | CN | disclosed |
| CN-111500026-A | Environment-friendly plastic and preparation method thereof | 安徽华猫软包装有限公司 | 2020-08-07 | — | — | CN | disclosed |