Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5946959 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL717410 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL8232360 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL937955 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL937953 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL697063 | 0.95 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL17314206 | 0.95 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL17314204 | 0.95 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL696758 | 0.95 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL697062 | 0.95 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111377911-B | Morpholine benzamide compound and application thereof | 江苏恩华药业股份有限公司 | 2022-05-24 | — | — | CN | disclosed |
| CN-111377911-A | Morpholine benzamide compound and application thereof | 江苏恩华药业股份有限公司 | 2020-07-07 | — | — | CN | disclosed |