Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232360 | 1.00 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL5946959 | 1.00 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL717410 | 1.00 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| SCHEMBL937955 | 1.00 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Bromide SCHEMBL28439253 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL697063 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL17314206 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL17314204 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL696758 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 | |
| Hydrochloric Acid SCHEMBL697062 | 0.98 | HRH4 (0.35) | HRH4GRIN1GRIN2ADRD3PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283004-B1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE | UNIV EDINBURGH (GB) | 2015-05-27 | — | — | EP | disclosed |
| US-8614209-B2 | Amido-thiophene compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2013-12-24 | — | — | US | disclosed |
| US-20130012545-A1 | Amido-Thiophene Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2013-01-10 | — | — | US | disclosed |
| US-8299063-B2 | Amido-thiophene compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-10-30 | — | — | US | disclosed |
| US-20110015178-A1 | Amido-Thiophene Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2011-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015178-A1 | Amido-Thiophene Compounds and Their Use | HSD11B1, HSD11B2, HSD17B1 | HRH4 3341/4885GRIN1 173/4885GRIN2A 246/4885 |
| US-20130012545-A1 | Amido-Thiophene Compounds and Their Use | HSD11B1, HSD11B2, HSD17B1 | HRH4 3341/4885GRIN1 173/4885GRIN2A 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.