SCHEMBL28439747

SCHEMBL28439747

COC(=O)c1cc(-c2ccncc2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.50
CYP46A1 Q9Y6A2 1/20 0.50
AXL P30530 1/20 0.50
ALDH1A1 P00352 3/20 0.49
AR P10275 1/20 0.45
MAPK1 P28482 1/20 0.43
NEK1 Q96PY6 1/20 0.43
KDM4E B2RXH2 3/20 0.42
KDM6B O15054 1/20 0.42
KDM5C P41229 1/20 0.42
KDM4C Q9H3R0 1/20 0.42
KDM2A Q9Y2K7 1/20 0.42
KDM3A Q9Y4C1 1/20 0.42
LCK P06239 1/20 0.42
GLA P06280 2/20 0.41
GAA P10253 2/20 0.41
IKBKE Q14164 1/20 0.41
TBK1 Q9UHD2 1/20 0.41
HPGDS O60760 1/20 0.41
HDAC1 Q13547 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30800091 0.93 ALDH1A1 (0.54) CYP46A1ALDH1A1ARMAPK1KDM4E
SCHEMBL29735406 0.88 ALDH1A1 (0.51) NR4A2AXLALDH1A1KDM4EGAA
SCHEMBL3712306 0.88 ALDH1A1 (0.51) NR4A2AXLALDH1A1KDM4EGAA
SCHEMBL13188268 0.86 EGFR (0.51) NR4A2AXLALDH1A1GAAHDAC1
SCHEMBL14210410 0.86 FDPS (0.48) NR4A2CYP46A1ALDH1A1ARMAPK1
SCHEMBL2958040 0.85 SLC6A4 (0.46) ALDH1A1KDM4EGAA
SCHEMBL13188759 0.85 DYRK1A (0.58) ALDH1A1KDM4EGAA
SCHEMBL27237665 0.85 ALDH1A1 (0.52) ALDH1A1KDM4E
SCHEMBL13545747 0.83 KDM4E (0.53) ALDH1A1MAPK1KDM4EKDM6BKDM5C
SCHEMBL3712320 0.82 CYP19A1 (0.60) NR4A2ALDH1A1NEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111378144-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed