Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 10/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24450111 | 0.72 | PIK3CA (0.40) | SLC22A12ENPP3ENPP1PARP1 | |
| SCHEMBL19708331 | 0.68 | MAP4K4 (0.34) | — | |
| SCHEMBL1269052 | 0.68 | APP (0.43) | — | |
| SCHEMBL28055645 | 0.68 | GLO1 (0.37) | — | |
| SCHEMBL17253109 | 0.65 | DGAT1 (0.37) | FGFR1FGFR4 | |
| SCHEMBL10837613 | 0.64 | NOTUM (0.59) | — | |
| SCHEMBL23327801 | 0.64 | SLC22A12 (0.41) | SLC22A12SLC22A6ENPP3ENPP1PARP1 | |
| SCHEMBL28659326 | 0.64 | PARP1 (0.41) | SLC22A12SLC22A6ABCG2FGFR1FGFR4 | |
| SCHEMBL21958555 | 0.64 | DGAT1 (0.38) | — | |
| SCHEMBL9789003 | 0.62 | TFPI2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108456207-B | Amide derivative and application thereof in cardiovascular and cerebrovascular aspects | 浙江药苑生物科技有限公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-108383838-B | Amide derivative and application thereof in hypertension, hyperlipidemia and atherosclerosis | 浙江药苑生物科技有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-108218865-B | Amide derivative and application thereof in cardiovascular and cerebrovascular aspects | 济南市儿童医院 | 2020-06-26 | — | — | CN | disclosed |