Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 1.00 |
| ▸ | ULK1 | O75385 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431751 | 0.92 | ALK (0.85) | ALKULK1PTK2METINSR | |
| SCHEMBL28436289 | 0.87 | ALK (1.00) | ALKPTK2MET | |
| SCHEMBL28432907 | 0.85 | ALK (0.84) | ALKULK1PTK2METINSR | |
| SCHEMBL28432882 | 0.85 | ALK (0.83) | ALKULK1PTK2INSRMAPK8 | |
| SCHEMBL28439025 | 0.84 | ALK (1.00) | ALKULK1PTK2METINSR | |
| SCHEMBL28442135 | 0.84 | ALK (1.00) | ALKULK1PTK2METINSR | |
| SCHEMBL28430786 | 0.80 | ALK (0.87) | ALKPTK2MET | |
| SCHEMBL28430835 | 0.78 | ALK (0.85) | ALKPTK2MET | |
| SCHEMBL17547512 | 0.78 | ALK (0.70) | ALKULK1PTK2METINSR | |
| SCHEMBL22144557 | 0.78 | ULK1 (0.81) | ALKULK1PTK2METINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484484-B | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111484484-A | 2, 4-diaryl aminopyrimidine derivative containing aromatic heterocycle and preparation and application thereof | 沈阳药科大学 | 2020-08-04 | — | — | CN | disclosed |