SCHEMBL28440687

SCHEMBL28440687

Cc1ccc(CC(Cl)(Cl)Cl)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
SKP2 Q13309 1/20 0.34
LMNA P02545 3/20 0.34
HTT P42858 1/20 0.34
CNR1 P21554 1/20 0.34
CYP3A4 P08684 3/20 0.33
NPC1 O15118 2/20 0.33
MAPT P10636 2/20 0.33
RAB9A P51151 2/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
CYP2C9 P11712 1/20 0.33
CCR2 P41597 1/20 0.33
NQO1 P15559 1/20 0.32
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26391639 0.84 ALDH1A1 (0.39) ALDH1A1ESR1ESR2NR1H4SKP2
SCHEMBL10629149 0.77 ALDH1A1 (0.41) ALDH1A1ESR1ESR2NR1H4SKP2
SCHEMBL5511404 0.76 SLC6A2 (0.52) ALDH1A1ESR1ESR2SKP2LMNA
SCHEMBL18433282 0.74 ALDH1A1 (0.38) ALDH1A1ESR1ESR2NR1H4SKP2
SCHEMBL28446506 0.73 IDO1 (0.46) ALDH1A1ESR1LMNAMAPTCYP1A2
SCHEMBL29377856 0.73 ALDH1A1 (0.40) ALDH1A1ESR1ESR2NR1H4LMNA
SCHEMBL540384 0.73 ALDH1A1 (0.40) ALDH1A1ESR1ESR2NR1H4LMNA
SCHEMBL24297529 0.72 ALDH1A1 (0.37) ALDH1A1ESR1ESR2SKP2LMNA
SCHEMBL19803175 0.72 ALDH1A1 (0.37) ALDH1A1ESR1ESR2SKP2LMNA
SCHEMBL31371688 0.72 ESR1 (0.61) ALDH1A1ESR1ESR2LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107417509-B Preparation method of phenylacetic acid compound 上海康鹏科技股份有限公司 2020-08-25 CN disclosed