Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439357 | 0.90 | JAK2 (0.51) | JAK2FLT3 | |
| SCHEMBL28437347 | 0.90 | JAK2 (0.50) | JAK2FLT3JAK1TYK2FGFR4 | |
| SCHEMBL28443651 | 0.87 | JAK2 (0.56) | JAK2FLT3 | |
| SCHEMBL24426203 | 0.81 | JAK2 (0.63) | JAK2FLT3JAK1TYK2FGFR4 | |
| SCHEMBL28435360 | 0.79 | JAK2 (0.56) | JAK2FLT3 | |
| SCHEMBL28437334 | 0.79 | JAK2 (0.42) | JAK2JAK1TYK2FGFR4JAK3 | |
| SCHEMBL28442721 | 0.78 | FGFR4 (0.58) | FGFR4 | |
| SCHEMBL28447915 | 0.78 | JAK2 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28443296 | 0.78 | JAK2 (0.54) | JAK2FLT3JAK3 | |
| SCHEMBL28441098 | 0.77 | JAK2 (0.61) | JAK2FLT3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |