Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437334 | 0.89 | JAK2 (0.42) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28439357 | 0.88 | JAK2 (0.51) | JAK2 | |
| SCHEMBL28441102 | 0.87 | — | — | |
| SCHEMBL28447910 | 0.79 | JAK3 (0.65) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28437347 | 0.78 | JAK2 (0.50) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28442019 | 0.78 | — | — | |
| SCHEMBL28441106 | 0.78 | JAK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL28897516 | 0.77 | PTK2 (0.60) | JAK3 | |
| SCHEMBL28451616 | 0.77 | — | — | |
| SCHEMBL28441100 | 0.73 | JAK2 (0.61) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |