Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18114209 | 0.81 | SYK (0.36) | CHRNB2CHRNA4 | |
| SCHEMBL18114249 | 0.79 | ALDH1A1 (0.38) | ALDH1A1PDK2 | |
| SCHEMBL2178430 | 0.79 | NQO1 (0.38) | CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL21795752 | 0.78 | MAPT (0.43) | KDM4ELMNA | |
| SCHEMBL21795744 | 0.78 | CHRNB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL18114281 | 0.77 | — | — | |
| SCHEMBL28783617 | 0.75 | — | — | |
| SCHEMBL1022718 | 0.72 | — | — | |
| SCHEMBL18114202 | 0.72 | CYP11B1 (0.31) | — | |
| SCHEMBL18114246 | 0.71 | MEN1 (0.34) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | claimed |
| CN-111689963-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-09-22 | — | — | CN | claimed |
| CN-114615995-A | Combined inhibition of PD-1, TGF beta and ATM and radiotherapy for cancer treatment | 阿雷斯贸易股份有限公司 | 2022-06-10 | — | — | CN | disclosed |
| CN-111747952-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-111689963-A | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-107889488-B | Imidazoquinolinones and their use as ATM kinase inhibitors | 默克专利股份公司 | 2020-08-11 | — | — | CN | disclosed |