Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18328497 | 1.00 | BTK (0.34) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL21287726 | 0.87 | BTK (0.37) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL21287164 | 0.84 | BTK (0.37) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL23028470 | 0.84 | CTSK (0.34) | BTKMEN1MAPK1KMT2ANFKB1 | |
| SCHEMBL8319039 | 0.84 | GAA (0.39) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL21287163 | 0.83 | BTK (0.36) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL22814480 | 0.83 | BTK (0.36) | BTKMEN1MAPK1KMT2AGAA | |
| SCHEMBL20337372 | 0.82 | BTK (0.34) | BTKMEN1MAPK1KMT2AEPHX2 | |
| SCHEMBL20337417 | 0.82 | BTK (0.34) | BTKMEN1MAPK1KMT2AEPHX2 | |
| SCHEMBL20337488 | 0.81 | SSTR4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625028-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-107922388-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-107787323-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-09-01 | — | — | CN | disclosed |