Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30497559 | 0.83 | STAT3 (0.40) | STAT3STAT1 | |
| SCHEMBL8974777 | 0.82 | NPC1 (0.39) | STAT3STAT1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL28455870 | 0.82 | L3MBTL1 (0.37) | NPC1RAB9A | |
| SCHEMBL28788096 | 0.81 | STAT3 (0.37) | STAT3STAT1 | |
| SCHEMBL30023006 | 0.81 | STAT3 (0.41) | STAT3STAT1 | |
| Hydrochloric Acid SCHEMBL8975057 | 0.81 | NPC1 (0.38) | STAT3STAT1NPC1RAB9A | |
| SCHEMBL28247856 | 0.81 | STAT3 (0.33) | STAT3STAT1 | |
| SCHEMBL28886041 | 0.81 | STAT3 (0.33) | STAT3STAT1 | |
| Toluene SCHEMBL1978986 | 0.80 | STAT3 (0.44) | STAT3STAT1NPC1RAB9A | |
| SCHEMBL28835903 | 0.80 | STAT3 (0.36) | STAT3STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109603444-B | Method for promoting oxygen and nitrogen separation of transfer membrane by using axial chlorine-containing metalloporphyrin as oxygen carrier | 中国科学院过程工程研究所 | 2020-08-04 | — | — | CN | disclosed |