Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.50 |
| ▸ | CYBB | P04839 | 3/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NOX5 | Q96PH1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723239 | 0.87 | NOX4 (0.38) | NOX4CYBBNOX1CYP3A4 | |
| SCHEMBL1301985 | 0.78 | NOX4 (0.50) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL2846433 | 0.78 | NOX4 (0.56) | NOX4CYBBNOX1CYP3A4 | |
| SCHEMBL1723241 | 0.78 | NOX4 (0.53) | NOX4CYBBNOX1CYP3A4 | |
| SCHEMBL1302005 | 0.76 | NOX4 (0.56) | NOX4CYBBNOX1CYP3A4 | |
| SCHEMBL1302490 | 0.72 | NOX4 (0.55) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL1302126 | 0.69 | NOX4 (0.60) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL1303017 | 0.67 | NOX4 (1.00) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL1302427 | 0.66 | NOX4 (0.58) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL2218101 | 0.65 | NOX4 (0.81) | NOX4CYBBNOX1NOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166010-A1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYO TEX SA (CH) | 2010-03-24 | — | — | EP | claimed |
| WO-2010035221-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |