Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.55 |
| ▸ | EGFR | P00533 | 11/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | ITK | Q08881 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924738 | 0.88 | BTK (0.69) | BTKEGFRJAK2JAK3 | |
| SCHEMBL28447678 | 0.85 | BTK (0.53) | BTKEGFRJAK2JAK3ITK | |
| SCHEMBL15814594 | 0.80 | EGFR (0.74) | BTKEGFRJAK2JAK3ITK | |
| SCHEMBL9945478 | 0.80 | BTK (0.67) | BTKEGFR | |
| SCHEMBL28445845 | 0.79 | EGFR (0.60) | BTKEGFRITK | |
| SCHEMBL9923766 | 0.78 | BTK (0.74) | BTKEGFRITK | |
| SCHEMBL9945480 | 0.78 | BTK (0.69) | BTKEGFRITK | |
| SCHEMBL18970176 | 0.77 | BTK (0.60) | BTKEGFRJAK2JAK3ITK | |
| SCHEMBL28059334 | 0.77 | BTK (0.85) | BTKEGFRJAK2JAK3ITK | |
| SCHEMBL12519708 | 0.77 | BTK (0.82) | BTKEGFRJAK2JAK3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-B | Substituted aminopyrimidine derivative and preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2020-09-04 | — | — | CN | disclosed |