Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841805 | 0.89 | CTSK (0.36) | CTSKPIN1NOTUMMETABL1 | |
| SCHEMBL2837038 | 0.85 | CTSK (0.39) | CTSKNOTUMMETABL1MAPK1 | |
| SCHEMBL2841496 | 0.84 | CTSK (0.36) | CTSKPIN1NOTUMMETABL1 | |
| SCHEMBL213733 | 0.83 | PIN1 (0.33) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL212204 | 0.83 | PIN1 (0.33) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL212203 | 0.83 | PIN1 (0.33) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL212202 | 0.83 | PIN1 (0.33) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL213734 | 0.83 | PIN1 (0.33) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL212721 | 0.82 | CTSK (0.35) | CTSKPIN1NOTUMMETMAPK1 | |
| SCHEMBL212719 | 0.82 | CTSK (0.35) | CTSKPIN1NOTUMMETMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |