Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.65 |
| ▸ | JAK1 | P23458 | 3/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | SYK | P43405 | 5/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437333 | 0.87 | JAK2 (0.50) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL28441100 | 0.86 | JAK2 (0.61) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL24426201 | 0.86 | JAK2 (0.64) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL28441103 | 0.81 | MAPK9 (0.47) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL28447917 | 0.80 | MAPK9 (0.44) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL28650663 | 0.79 | JAK1 (1.00) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28447915 | 0.79 | JAK2 (0.45) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL13311507 | 0.77 | JAK2 (0.57) | JAK3JAK1JAK2TYK2SYK | |
| SCHEMBL2551874 | 0.75 | CSF1R (0.56) | JAK3JAK1JAK2TYK2MAPK9 | |
| SCHEMBL28442012 | 0.75 | JAK2 (0.57) | JAK2MAPK9MAPK10SYKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |