SCHEMBL28448245

SCHEMBL28448245

O=C=Nc1ccc2c(c1)-c1cc(N=C=O)ccc1-2

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.56
MAPK1 P28482 1/20 0.56
CYP3A4 P08684 4/20 0.52
TRPA1 O75762 1/20 0.52
TSHR P16473 1/20 0.48
CYP1A2 P05177 1/20 0.39
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28562992 1.00 TDP1 (0.56) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL940920 0.89 MAPK1 (0.50) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL542807 0.84 MAPK1 (0.50) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL7061343 0.83 MAPK1 (0.46) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL2770967 0.79 MAPK1 (0.73) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL2156677 0.79 MAPK1 (0.50) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL667517 0.79 CYP3A4 (0.62) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL11351193 0.79 CYP2C19 (0.50) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL22111494 0.79 CYP3A4 (0.56) TDP1MAPK1CYP3A4TRPA1TSHR
SCHEMBL9480950 0.79 TDP1 (0.46) TDP1MAPK1CYP3A4TRPA1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107207851-B Method for producing photochromic cured product 株式会社德山 2020-07-17 CN disclosed