Benzene

Benzene

SCHEMBL28448554

Cc1ccc(C)c(F)c1.c1ccccc1

nearest known ligand 0.48

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.48
HDAC1 Q13547 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
TDP1 Q9NUW8 3/20 0.44
ALDH1A1 P00352 1/20 0.44
TAAR1 Q96RJ0 1/20 0.41
NFE2L2 Q16236 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
CYP2A6 P11509 3/20 0.39
CYP1A2 P05177 3/20 0.39
TP53 P04637 1/20 0.39
KIF11 P52732 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30527 0.95
SCHEMBL30167752 0.95
P-Xylene SCHEMBL28885091 0.92 ACHE (0.48) ACHEHDAC1HDAC6TDP1ALDH1A1
Nitrogen SCHEMBL27314581 0.90 HDAC1 (0.45) ACHEHDAC1HDAC6TDP1ALDH1A1
Methoxymethane SCHEMBL27503637 0.87 HDAC1 (0.44) ACHEHDAC1HDAC6TDP1ALDH1A1
Acetic Acid SCHEMBL29059065 0.86 HDAC1 (0.53) HDAC1HDAC6ALDH1A1KMT2AMEN1
P-Xylene SCHEMBL28217850 0.80 NFE2L2 (0.42) ACHEHDAC1HDAC6TDP1ALDH1A1
SCHEMBL14365640 0.78 AKR1C3 (0.54) HDAC1HDAC6TAAR1
SCHEMBL10018722 0.78 AKR1C3 (0.54) HDAC1HDAC6TAAR1
SCHEMBL10014184 0.75 NISCH (0.46) ACHEHDAC1HDAC6TDP1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106977364-B Synthetic method of octafluoro-p-xylene ring dimer 常州市骏佳化工有限公司 2020-09-01 CN disclosed