Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17292541 | 0.86 | CYP11B1 (0.37) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL13154670 | 0.71 | CHRNB2 (0.33) | CYP1A2EGFR | |
| SCHEMBL18289475 | 0.71 | AHR (0.59) | AHRTDP2CMA1PDE3BPDE3A | |
| SCHEMBL29876428 | 0.70 | AHR (0.40) | AHRAURKADAPK3PRKD3PIM1 | |
| SCHEMBL29288694 | 0.70 | CES1 (0.41) | PDE3BPDE3ACASP3CASP7CASP6 | |
| SCHEMBL31712925 | 0.69 | SRC (0.33) | EGFR | |
| SCHEMBL29424231 | 0.67 | CHEK1 (0.49) | AHRBCL6CHEK1AURKADAPK3 | |
| SCHEMBL322055 | 0.67 | CHEK1 (0.49) | AHRBCL6CHEK1AURKADAPK3 | |
| SCHEMBL28899699 | 0.67 | MKNK2 (0.33) | — | |
| SCHEMBL31712908 | 0.66 | EGFR (0.33) | CYP1A2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727385-B | Preparation method of polysubstituted dihydropyrimido indolone derivative | 青岛科技大学 | 2020-09-08 | — | — | CN | disclosed |