SCHEMBL28450407

SCHEMBL28450407

O=[N+]([O-])c1[c]c([N+](=O)[O-])cnc1

nearest known ligand 0.31

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
MAPT P10636 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4927320 0.84 ACHE (0.31) ALDH1A1
SCHEMBL4928589 0.84
SCHEMBL4925952 0.84 ALDH1A1 (0.33) ALDH1A1LMNAMAPK1HTT
SCHEMBL447325 0.72
SCHEMBL58486 0.70 TSHR (0.46) ALDH1A1ALOX15LMNAHTTKMT2A
SCHEMBL18479 0.68 CYP19A1 (0.52) ALDH1A1HPGDALOX15LMNAMAPK1
SCHEMBL28195381 0.67 ERN1 (0.37) ALDH1A1LMNAMEN1KMT2A
SCHEMBL3296075 0.65 ALDH1A1 (0.36) ALDH1A1HPGDALOX15LMNAMAPK1
SCHEMBL5252228 0.65 CYP19A1 (0.55) ALDH1A1LMNAHTT
SCHEMBL2045321 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111556872-A Synthesis of boronic ester derivatives and uses thereof 梅琳塔治疗公司 2020-08-18 CN disclosed