SCHEMBL28452138

SCHEMBL28452138

Cc1c(F)cccc1-n1nnnc1[S+](C)[O-]

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 18/20 0.41
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28188978 0.87 KCNN4 (0.39) KCNN4ALDH1A1
SCHEMBL28188992 0.87 KCNN4 (0.50) KCNN4
SCHEMBL28458370 0.84 P2RX7 (0.42) KCNN4
SCHEMBL28189014 0.83 ALDH1A1 (0.53) KCNN4ALDH1A1TSHR
SCHEMBL28189001 0.82 ALDH1A1 (0.46) KCNN4ALDH1A1TSHR
SCHEMBL28188353 0.79 ALDH1A1 (0.55) KCNN4ALDH1A1TSHR
SCHEMBL1493508 0.76 KCNN4 (0.44) KCNN4ALDH1A1TSHR
SCHEMBL28461340 0.76 KCNN4 (0.48) KCNN4ALDH1A1TSHR
SCHEMBL28455981 0.75 NPC1 (0.44) KCNN4ALDH1A1
SCHEMBL28461418 0.75 TP53 (0.36) KCNN4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107501198-B Sulfoxide tetrazole derivative and preparation method and application thereof 南京农业大学 2020-08-18 CN claimed
CN-107501198-B Sulfoxide tetrazole derivative and preparation method and application thereof 南京农业大学 2020-08-18 CN disclosed