Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 7/20 | 0.46 |
| ▸ | CTSL | P07711 | 5/20 | 0.46 |
| ▸ | CTSB | P07858 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19357462 | 0.85 | ABCB1 (0.52) | CTSKCTSLCTSBCTSSKMT2A | |
| SCHEMBL4744008 | 0.76 | CA12 (0.55) | CA12CA1CA2CA9CTSK | |
| SCHEMBL1494027 | 0.76 | ALDH1A1 (0.44) | CTSKCTSLCTSBCTSSATM | |
| SCHEMBL30191411 | 0.75 | ABCB1 (0.51) | CTSKCTSLCTSBCTSSKMT2A | |
| SCHEMBL25246539 | 0.75 | CA12 (0.50) | CA12CA1CA2CA9LMNA | |
| SCHEMBL1947879 | 0.74 | ALDH1A1 (0.65) | CA12CA1CA2CA9LMNA | |
| SCHEMBL32678475 | 0.74 | ABCB1 (0.50) | CTSKCTSLCTSBCTSSLMNA | |
| SCHEMBL32678478 | 0.74 | ABCB1 (0.50) | CTSKCTSLCTSBCTSSLMNA | |
| SCHEMBL20299925 | 0.74 | CA12 (0.52) | CA12CA1CA2CA9CTSK | |
| SCHEMBL32678476 | 0.74 | ABCB1 (0.50) | CTSKCTSLCTSBCTSSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |