Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 6/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184417 | 1.00 | GPR119 (0.40) | GPR119EPHX1HPGDEPHX2STS | |
| SCHEMBL31184121 | 0.88 | GPR119 (0.39) | GPR119EPHX1HPGDEPHX2STS | |
| SCHEMBL28446272 | 0.88 | GPR119 (0.39) | GPR119EPHX1HPGDEPHX2STS | |
| SCHEMBL28456488 | 0.86 | NAMPT (0.31) | — | |
| SCHEMBL31184402 | 0.82 | GPR119 (0.38) | GPR119EPHX1EPHX2USP2SMN1; SMN2 | |
| SCHEMBL28360243 | 0.82 | GPR119 (0.38) | GPR119EPHX1EPHX2USP2SMN1; SMN2 | |
| SCHEMBL28448337 | 0.82 | GPR119 (0.38) | GPR119EPHX1EPHX2USP2SMN1; SMN2 | |
| SCHEMBL29564055 | 0.82 | GPR119 (0.38) | GPR119EPHX1EPHX2USP2SMN1; SMN2 | |
| SCHEMBL28356333 | 0.82 | GPR119 (0.38) | GPR119EPHX1EPHX2USP2SMN1; SMN2 | |
| SCHEMBL29715656 | 0.81 | EPHX1 (0.42) | GPR119EPHX1HPGDEPHX2STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112625028-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-107922388-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-107787323-B | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2020-09-01 | — | — | CN | disclosed |