SCHEMBL28454792

SCHEMBL28454792

C[C@H](NC(=O)c1cn(C)nc1C(F)F)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.52
ALDH1A1 P00352 5/20 0.51
KDM4E B2RXH2 2/20 0.51
HPGD P15428 2/20 0.51
LMNA P02545 2/20 0.51
HSD17B10 Q99714 1/20 0.51
NPC1 O15118 1/20 0.50
MAPK1 P28482 1/20 0.49
POLB P06746 2/20 0.48
HTT P42858 1/20 0.48
PHGDH O43175 1/20 0.48
PDE2A O00408 1/20 0.47
GAA P10253 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
CNR2 P34972 5/20 0.46
CNR1 P21554 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28455716 1.00 ACACB (0.52) ACACBALDH1A1KDM4EHPGDLMNA
SCHEMBL28454793 1.00 ACACB (0.52) ACACBALDH1A1KDM4EHPGDLMNA
SCHEMBL28456502 0.88 ACACB (0.53) ACACBALDH1A1HPGDLMNAPOLB
SCHEMBL28458876 0.86 ACACB (0.52) ACACBALDH1A1LMNAHSD17B10MAPK1
SCHEMBL4174184 0.83 TACR3 (0.48) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL28509438 0.83 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL28510286 0.83 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL28509439 0.83 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDLMNAHSD17B10
SCHEMBL13666302 0.81 ACACB (0.42) ACACBLMNAMAPK1POLBGAA
SCHEMBL2721421 0.81 ACACB (0.54) ACACBALDH1A1PDE2ACNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108863934-B Application of 1-methyl-3-difluoromethyl-1H-pyrazole-4-amide derivative in preparation of herbicide 浙江工业大学 2020-09-08 CN disclosed