SCHEMBL28456502

SCHEMBL28456502

CC(NC(=O)c1cn(C)nc1C(F)F)c1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.53
ALDH1A1 P00352 1/20 0.47
GPR139 Q6DWJ6 3/20 0.46
CLK1 P49759 2/20 0.44
CNR1 P21554 1/20 0.44
PTGER4 P35408 7/20 0.44
LMNA P02545 2/20 0.44
POLB P06746 1/20 0.44
PTGER2 P43116 2/20 0.43
PDE2A O00408 1/20 0.41
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PTGDR Q13258 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28454793 0.88 ACACB (0.52) ACACBALDH1A1CNR1LMNAPOLB
SCHEMBL28454792 0.88 ACACB (0.52) ACACBALDH1A1CNR1LMNAPOLB
SCHEMBL28455716 0.88 ACACB (0.52) ACACBALDH1A1CNR1LMNAPOLB
SCHEMBL28458876 0.87 ACACB (0.52) ACACBALDH1A1CNR1PTGER4LMNA
SCHEMBL10297485 0.84 MEN1 (0.53) ACACBALDH1A1GPR139CNR1LMNA
SCHEMBL2721421 0.81 ACACB (0.54) ACACBALDH1A1CNR1PDE2A
SCHEMBL15525109 0.80 ACACB (0.42) ACACBGPR139PTGER4LMNAPOLB
SCHEMBL2721240 0.79 ACACB (0.42) ACACBGPR139PTGER4POLB
SCHEMBL2266545 0.79 AHR (0.42) ACACBALDH1A1LMNAPOLB
SCHEMBL29271548 0.78 ALDH1A1 (0.39) ACACBALDH1A1LMNAPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108863934-B Application of 1-methyl-3-difluoromethyl-1H-pyrazole-4-amide derivative in preparation of herbicide 浙江工业大学 2020-09-08 CN disclosed