Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 11/20 | 0.88 |
| ▸ | APP | P05067 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28447648 | 0.94 | IDH2 (1.00) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28450991 | 0.85 | IDH2 (0.82) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28450615 | 0.84 | IDH2 (1.00) | IDH2 | |
| SCHEMBL28451633 | 0.83 | IDH2 (0.79) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL30568814 | 0.83 | APP (0.79) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL1391344 | 0.83 | APP (0.79) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28460991 | 0.83 | IDH2 (0.89) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28451054 | 0.83 | IDH2 (0.89) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28456839 | 0.83 | IDH2 (0.89) | IDH2APPLMNAMAPTMAPK1 | |
| SCHEMBL28459484 | 0.82 | APP (0.65) | IDH2APPLMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662242-B | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2023-10-24 | — | — | CN | disclosed |
| CN-111662242-A | Heterocyclic IDH mutant inhibitor, preparation method and application thereof | 中国药科大学 | 2020-09-15 | — | — | CN | disclosed |