Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dibenzoylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibenzoylmethane SCHEMBL28453613 | 0.81 | HPGD (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL28899246 | 0.81 | HPGD (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| SCHEMBL3208519 | 0.78 | L3MBTL1 (0.46) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL28462129 | 0.77 | KMT2A (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL28899245 | 0.77 | KMT2A (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL28459361 | 0.77 | KMT2A (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL28456807 | 0.77 | KMT2A (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL21800928 | 0.77 | KMT2A (0.90) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL39582 | 0.77 | MEN1 (1.00) | KMT2AMAPTMEN1SMN1; SMN2HPGD | |
| Dibenzoylmethane SCHEMBL1704711 | 0.77 | MEN1 (1.00) | KMT2AMAPTMEN1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499777-A | Ultrahigh molecular weight polyethylene catalyst, and preparation method and application thereof | 江苏扬农化工集团有限公司 | 2020-08-07 | — | — | CN | disclosed |