⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28846249 | 0.76 | ALDH1A1 (0.34) | — | |
| SCHEMBL11213831 | 0.73 | — | — | |
| SCHEMBL18069668 | 0.72 | — | — | |
| SCHEMBL1069137 | 0.70 | ALDH1A1 (0.33) | — | |
| SCHEMBL27710857 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL9218772 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL6130000 | 0.67 | TSHR (0.33) | — | |
| SCHEMBL6129980 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL2180984 | 0.65 | — | — | |
| SCHEMBL27723530 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245020-B1 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2014-01-15 | — | — | EP | disclosed |
| EP-2245020-B1 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8383657-B2 | Thiazolylidine urea and amide derivatives and methods of use thereof | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383657-B2 | Thiazolylidine urea and amide derivatives and methods of use thereof | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| CN-101903364-A | Thiazoline urea and amide derivatives and methods of use thereof | ABBOTT LAB | 2010-12-01 | — | — | CN | disclosed |
| EP-2245020-A2 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009086163-A2 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009086163-A2 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090163470-A1 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090163470-A1 | THIAZOLYLIDINE UREA AND AMIDE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-06-25 | — | — | US | disclosed |
| US-7214801-B2 | Condensation reagents and a process for their preparation | LANXESS DEUTSCHLAND GMBH (DE) | 2007-05-08 | — | — | US | disclosed |
| US-7064216-B2 | Condensation reagents and a process for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 2006-06-20 | — | — | US | disclosed |
| US-20050267174-A1 | Condensation reagents and a process for their preparation | RUDOLPH JOACHIM | 2005-12-01 | — | — | US | disclosed |
| US-20020156287-A1 | Condensation reagents and a process for their preparation | LANXESS DEUTSCHLAND GMBH (DE) | 2002-10-24 | — | — | US | disclosed |