Nitromethane

Nitromethane

SCHEMBL28456989

CCC(C(=O)O)[N+](=O)[O-].C[N+](=O)[O-]

nearest known ligand 0.39

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
CPA1 P15085 2/20 0.35
HIF1A Q16665 2/20 0.32
TSHR P16473 1/20 0.32
HPGD P15428 1/20 0.32
CA2 P00918 1/20 0.31
MAPK1 P28482 1/20 0.31
CHRM1 P11229 1/20 0.31
AKR1A1 P14550 1/20 0.31
CHRM3 P20309 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
ADRA1A P35348 1/20 0.31
HRH1 P35367 1/20 0.31
DRD3 P35462 1/20 0.31
SLC6A3 Q01959 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
SLC1A3 P43003 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1008129 0.95
Hydrochloric Acid SCHEMBL11628885 0.93 ALDH1A1 (0.41) ALDH1A1CPA1HIF1ATSHRHPGD
SCHEMBL9851962 0.79 CHRM1 (0.48) ALDH1A1CPA1TSHRCA2MAPK1
SCHEMBL11507199 0.79 ALDH1A1 (0.41) ALDH1A1TSHR
SCHEMBL11694182 0.77 ALDH1A1 (0.39) ALDH1A1TSHR
Potassium Ion SCHEMBL11694177 0.77 ALDH1A1 (0.39) ALDH1A1TSHR
Ammonia Solution, Strong SCHEMBL11867769 0.77 ALDH1A1 (0.39) ALDH1A1TSHR
SCHEMBL11627708 0.76
SCHEMBL11508090 0.76
SCHEMBL11507296 0.76 CES2 (0.40) ALDH1A1TSHRHDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108658883-B Method for synthesizing isoxazole derivative by catalyzing aryl aldehyde and nitromethane with copper salt 沅江华龙催化科技有限公司 2020-06-16 CN disclosed