Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.44 |
| ▸ | ITGAV | P06756 | 2/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL31082263 | 0.88 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAITGB3ITGAV | |
| Citric Acid SCHEMBL27897976 | 0.84 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| SCHEMBL28458113 | 0.81 | GAA (0.51) | ALDH1A1KDM4ELMNAITGB3ITGAV | |
| Citric Acid SCHEMBL27917194 | 0.81 | KDM4E (0.49) | ALDH1A1KDM4ECYP1A2CYP2D6SLC13A5 | |
| Citric Acid SCHEMBL28587369 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL2237856 | 0.77 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL5874613 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL29049248 | 0.75 | POLB (0.47) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| Citric Acid SCHEMBL31082127 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMEN1CYP1A2 | |
| SCHEMBL787 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916215-A | Transdermal microdosing delivery of hallucinogen derivatives | 长矛治疗股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115038451-A | Multimodal compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115003279-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-113613650-A | Muscarinic acetylcholine receptor subtype 4 antagonists for the treatment of anemia | 冷泉港实验室 | 2021-11-05 | — | — | CN | disclosed |
| CN-112585690-A | System and method for producing individualized individual unit doses containing a pharmaceutically active substance | 阿奎斯蒂弗医疗股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-111683653-A | Methods and compositions for topical delivery | 伊拉斯吹斯制药有限公司 | 2020-09-18 | — | — | CN | disclosed |