Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL5179943 | 0.85 | CYP2C19 (0.39) | ALDH1A1KDM4ECYP1A2KMT2AHIF1A | |
| Citric Acid SCHEMBL27897976 | 0.84 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Malonic Acid SCHEMBL5874902 | 0.82 | GAA (0.41) | ALDH1A1KDM4EKMT2AHIF1ACYP2C19 | |
| Succinic Acid SCHEMBL5874073 | 0.82 | NR4A2 (0.41) | ALDH1A1KDM4EMEN1KMT2AHIF1A | |
| Propionic Acid SCHEMBL5874238 | 0.82 | HIF1A (0.39) | ALDH1A1KDM4EKMT2AHIF1ACYP2C19 | |
| Bicarbonate SCHEMBL5874331 | 0.82 | KMT2A (0.41) | ALDH1A1KDM4ECYP1A2CYP2D6MEN1 | |
| Chloroacetic Acid SCHEMBL5874302 | 0.81 | HIF1A (0.38) | ALDH1A1KDM4EMEN1KMT2AHIF1A | |
| Acetic Acid SCHEMBL1047016 | 0.80 | HPGD (0.40) | ALDH1A1KDM4ECYP1A2CYP2D6MEN1 | |
| Oxalic Acid SCHEMBL5179301 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4ECYP1A2CYP2D6KMT2A | |
| Oxalic Acid SCHEMBL153610 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KDM4ECYP1A2CYP2D6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |