Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2688583 | 0.82 | HTT (0.34) | HTT | |
| SCHEMBL15050027 | 0.80 | HSD11B1 (0.34) | — | |
| SCHEMBL2848744 | 0.80 | OPRM1 (0.34) | — | |
| SCHEMBL15808505 | 0.72 | — | — | |
| SCHEMBL2687429 | 0.70 | — | — | |
| SCHEMBL5216741 | 0.68 | HTT (0.49) | HTT | |
| SCHEMBL3276057 | 0.68 | HTT (0.49) | HTT | |
| SCHEMBL3740451 | 0.68 | HTT (0.49) | HTT | |
| SCHEMBL3963948 | 0.67 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL2803851 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683057-B2 | 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (1-acetyl-piperidin-4-yl)-amide; inhibition of 5' AMP-activated protein kinase (AMPK) | TYROGENEX, INC. (US) | 2010-03-23 | — | — | US | claimed |