SCHEMBL28458281

SCHEMBL28458281

CC(=O)C(C)C(=O)c1ccccc1.[Nd]

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.53
LMNA P02545 4/20 0.50
MAPT P10636 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
ATM Q13315 2/20 0.50
PGR P06401 1/20 0.50
ADRA2A P08913 1/20 0.50
ADRA2B P18089 1/20 0.50
HTR2A P28223 1/20 0.50
HRH1 P35367 1/20 0.50
KCNH2 Q12809 1/20 0.50
XBP1 P17861 1/20 0.50
ALDH1A1 P00352 3/20 0.48
CYP3A4 P08684 2/20 0.48
CES2 O00748 4/20 0.48
CES1 P23141 4/20 0.48
TSHR P16473 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3274886 0.98 KMT2A (0.55) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL20944778 0.98 KMT2A (0.55) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL1397470 0.88 KMT2A (0.58) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL17973359 0.85 SMN1; SMN2 (0.61) KMT2ALMNAMAPTL3MBTL1SMN1; SMN2
SCHEMBL649287 0.84 KMT2A (0.55) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL8823334 0.84 KMT2A (0.55) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL14396094 0.81 HPGD (0.65) KMT2ALMNAMAPTL3MBTL1SMN1; SMN2
SCHEMBL6575621 0.80 KMT2A (0.51) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL11408876 0.80 KMT2A (0.51) KMT2ALMNAMAPTTDP1L3MBTL1
SCHEMBL6920855 0.80 PGR (0.53) KMT2ALMNAMAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117178209-A Optical article, spectacle lens and spectacles 株式会社德山 2023-12-05 CN disclosed
CN-114846047-A Moisture-curable polyurethane composition and laminate 株式会社德山 2022-08-02 CN disclosed
CN-111727402-B Functional laminate and functional lens using same 株式会社德山 2022-07-15 CN disclosed
CN-113646281-A Photochromic optical article and method of making same 株式会社德山 2021-11-12 CN disclosed
CN-109476973-B Adhesive composition, laminate, and optical article using the laminate 株式会社德山 2021-04-27 CN disclosed
CN-111727402-A Functional laminate and functional lens using same 株式会社德山 2020-09-29 CN disclosed