SCHEMBL28458573

SCHEMBL28458573

CCn1c(N)c(NC(=O)/C=C/c2ccc(OCCOC)c(OCCOC)c2)c(=O)n(CC)c1=O

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FDPS P14324 3/20 0.44
BCHE P06276 15/20 0.43
ACHE P22303 15/20 0.43
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 2/20 0.43
HPGD P15428 1/20 0.43
KDM4E B2RXH2 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28452461 0.96 MEN1 (0.46) FDPSBCHEACHEMEN1ALDH1A1
SCHEMBL28460284 0.96 FDPS (0.50) FDPSBCHEACHEMEN1ALDH1A1
SCHEMBL28458544 0.92 HPGD (0.39) FDPSBCHEACHEMEN1ALDH1A1
SCHEMBL28450298 0.92 HDAC3 (0.39) FDPSBCHEACHEMEN1ALDH1A1
SCHEMBL28456104 0.88 SAE1 (0.45) MEN1ALDH1A1KMT2AKDM4ELMNA
SCHEMBL30632573 0.88 MEN1 (0.52) MEN1ALDH1A1KMT2AHPGDKDM4E
SCHEMBL30036391 0.87 NPC1 (0.39) MEN1ALDH1A1KMT2AKDM4ELMNA
SCHEMBL28530196 0.87 NPC1 (0.39) MEN1ALDH1A1KMT2AKDM4ELMNA
SCHEMBL28452458 0.86 CYP1A2 (0.42) BCHEACHEALDH1A1HPGDKDM4E
SCHEMBL28515989 0.81 NPC1 (0.48) MEN1ALDH1A1KMT2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110041331-B Styrylxanthine derivative and use thereof 广东东阳光药业有限公司 2020-08-07 CN disclosed