Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29593632 | 1.00 | CRHR1 (0.37) | CRHR1HSP90AB1PTGS2MAPK14BRD4 | |
| SCHEMBL29593489 | 0.91 | GLP1R (0.37) | CRHR1HSP90AB1PTGS2MAPK14BRD4 | |
| SCHEMBL28461960 | 0.91 | GLP1R (0.37) | CRHR1HSP90AB1PTGS2MAPK14BRD4 | |
| SCHEMBL29593211 | 0.88 | PTGS2 (0.37) | HSP90AB1PTGS2MAPK14BRD4 | |
| SCHEMBL28464519 | 0.88 | PTGS2 (0.37) | HSP90AB1PTGS2MAPK14BRD4 | |
| SCHEMBL1061521 | 0.83 | HSP90AB1 (0.44) | CRHR1HSP90AB1 | |
| SCHEMBL28461712 | 0.80 | KCNH2 (0.37) | PTGS2MAPK14BRD4GRIN2B | |
| SCHEMBL29594254 | 0.80 | KCNH2 (0.37) | PTGS2MAPK14BRD4GRIN2B | |
| SCHEMBL28900014 | 0.80 | ABL1 (0.42) | PTGS2MAPK14BRD4GRIN2B | |
| SCHEMBL29594311 | 0.79 | MAPK14 (0.36) | PTGS2MAPK14BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |