Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | HAT1 | O14929 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28467009 | 0.87 | MAP2K1 (0.43) | MAP2K1CAMKK2GRM8GRM4MTNR1A | |
| SCHEMBL857532 | 0.84 | MAP2K1 (0.41) | MAP2K1GRM8GRM4AKT1KMT2A | |
| SCHEMBL1267600 | 0.80 | AXL (0.44) | MAP2K1AHRKMT2AMETAXL | |
| SCHEMBL21872999 | 0.80 | MAP2K1 (0.41) | MAP2K1KMT2AMETAXLBRD4 | |
| SCHEMBL22988870 | 0.77 | MAP2K1 (0.41) | MAP2K1GRM8GRM4MTNR1AMET | |
| SCHEMBL857798 | 0.76 | AXL (0.48) | MAP2K1GRM8GRM4MTNR1AAHR | |
| SCHEMBL1266772 | 0.75 | MAP2K1 (0.36) | MAP2K1GRM8GRM4AHRKMT2A | |
| SCHEMBL4653268 | 0.73 | MAP2K1 (0.36) | MAP2K1AHRKMT2AMETAXL | |
| SCHEMBL28463522 | 0.72 | MAP2K1 (0.33) | MAP2K1CAMKK2 | |
| SCHEMBL1266773 | 0.71 | DRD2 (0.35) | MAP2K1AKT1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110461849-B | CSF1R inhibitor and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-09-01 | — | — | CN | disclosed |
| CN-110461849-A | A kind of CSF1R inhibitor and its preparation method and application | ABBISKO THERAPEUTICS CO LTD | 2019-11-15 | — | — | CN | disclosed |