Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Salicyladehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.75 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.75 |
| ▸ | ERN1 | O75460 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicyladehyde SCHEMBL531267 | 0.98 | TRIM24 (0.78) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL3379351 | 0.98 | TRIM24 (0.78) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL28961727 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL28410156 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL29091716 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL8857189 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL28454832 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL10486499 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL28369556 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 | |
| Salicyladehyde SCHEMBL28374710 | 0.96 | TRIM24 (0.75) | TRIM24TRIM33ERN1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111909371-B | Tetraalkenyl polyphenyl ether and preparation method thereof | 广东省石油与精细化工研究院 | 2022-12-27 | — | — | CN | claimed |
| CN-111793203-B | Polyphenyl ether and synthesis method thereof | 广东省石油与精细化工研究院 | 2022-12-27 | — | — | CN | claimed |
| CN-111909371-B | Tetraalkenyl polyphenyl ether and preparation method thereof | 广东省石油与精细化工研究院 | 2022-12-27 | — | — | CN | disclosed |
| CN-111793203-B | Polyphenyl ether and synthesis method thereof | 广东省石油与精细化工研究院 | 2022-12-27 | — | — | CN | disclosed |
| CN-111909371-A | Tetrallyl polyphenylene oxide and preparation method thereof | 广东省石油与精细化工研究院 | 2020-11-10 | — | — | CN | disclosed |
| CN-111793203-A | Polyphenyl ether and synthesis method thereof | 广东省石油与精细化工研究院 | 2020-10-20 | — | — | CN | disclosed |