Thiophene

Thiophene

SCHEMBL28465488

O=S1(=O)C=Cc2ccccc21.O=S1(=O)C=Cc2ccccc21.c1ccsc1

nearest known ligand 0.42

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Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
STAT3 P40763 1/20 0.42
MTOR P42345 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42
HIF1A Q16665 1/20 0.42
CA1 P00915 5/20 0.39
CA2 P00918 5/20 0.39
CA9 Q16790 5/20 0.39
PLCG2 P16885 1/20 0.33
GPR3 P46089 1/20 0.31
CA12 O43570 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL62430 0.88 CA9 (0.46) MEN1NPC1STAT3MTORRAB9A
SCHEMBL31003510 0.88 CA9 (0.46) MEN1NPC1STAT3MTORRAB9A
Water SCHEMBL27659746 0.86 CA9 (0.44) MEN1NPC1STAT3MTORRAB9A
Methoxymethane SCHEMBL10856175 0.80 CA9 (0.41) MEN1NPC1STAT3MTORRAB9A
Acetone SCHEMBL8996477 0.77 CA9 (0.39) MEN1NPC1STAT3MTORRAB9A
SCHEMBL386507 0.74 GPR3 (0.34) MEN1NPC1STAT3MTORRAB9A
SCHEMBL19744948 0.72 GPR3 (0.48) MEN1NPC1STAT3MTORRAB9A
Cyclohexylamine SCHEMBL4918979 0.70 CA1 (0.37) MEN1NPC1STAT3MTORRAB9A
SCHEMBL11036902 0.65 GPR3 (0.55) MEN1KMT2ACA1CA2CA9
SCHEMBL2376272 0.65 GPR3 (0.42) MEN1KMT2ACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113519072-A Radiation heat-resistant material 阿卜杜拉国王科学技术大学 2021-10-19 CN claimed
CN-111837251-A Non-fullerene and/or hole scavenger based active layer and optoelectronic device 阿卜杜拉国王科学技术大学 2020-10-27 CN claimed
CN-113519072-A Radiation heat-resistant material 阿卜杜拉国王科学技术大学 2021-10-19 CN disclosed
CN-111837251-A Non-fullerene and/or hole scavenger based active layer and optoelectronic device 阿卜杜拉国王科学技术大学 2020-10-27 CN disclosed