Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.86 |
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | SELL | P14151 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | SELE | P16581 | 1/20 | 0.50 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28714 | 0.92 | — | — | |
| Orcinol SCHEMBL68497 | 0.92 | — | — | |
| SCHEMBL11574035 | 0.92 | ALDH1A1 (1.00) | ALDH1A1BACE1ACHESELLSELP | |
| Orcinol SCHEMBL11445808 | 0.89 | ALDH1A1 (0.80) | ALDH1A1BACE1ACHESELLSELP | |
| SCHEMBL3808139 | 0.89 | ALDH1A1 (0.93) | ALDH1A1BACE1ACHESELLSELP | |
| SCHEMBL28868049 | 0.89 | ALDH1A1 (0.93) | ALDH1A1BACE1ACHESELLSELP | |
| Orcinol SCHEMBL11786364 | 0.89 | ALDH1A1 (0.80) | ALDH1A1BACE1ACHESELLSELP | |
| Orcinol SCHEMBL236740 | 0.89 | ALDH1A1 (0.80) | ALDH1A1BACE1ACHESELLSELP | |
| Hydrochloric Acid SCHEMBL7075578 | 0.89 | ALDH1A1 (0.93) | ALDH1A1BACE1ACHESELLSELP | |
| SCHEMBL30017927 | 0.89 | ALDH1A1 (0.93) | ALDH1A1BACE1ACHESELLSELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113929921-B | Covalent organic framework material with sulfydryl functionalized beta-keto enamine structure and preparation method and application thereof | 青岛理工大学 | 2022-12-20 | — | — | CN | claimed |
| CN-112295422-A | Calcium alginate-covalent organic framework material nanosheet-hydrolyzed polyacrylonitrile three-layer membrane and preparation and application thereof | 天津大学 | 2021-02-02 | — | — | CN | claimed |
| CN-115715940-A | Amphoteric cyclodextrin-based double-ligand metal-organic framework separation membrane and preparation method thereof | 浙江工业大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-113929921-B | Covalent organic framework material with sulfydryl functionalized beta-keto enamine structure and preparation method and application thereof | 青岛理工大学 | 2022-12-20 | — | — | CN | disclosed |
| CN-110339597-B | Preparation method of COF-F-loaded hydrophobic oil absorption sponge | 天津工业大学 | 2021-09-17 | — | — | CN | disclosed |
| CN-112295422-A | Calcium alginate-covalent organic framework material nanosheet-hydrolyzed polyacrylonitrile three-layer membrane and preparation and application thereof | 天津大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-111704196-A | Nano CuO/COF composite arsenic removal material and preparation method thereof | 杭州肄康新材料有限公司 | 2020-09-25 | — | — | CN | disclosed |