Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808537 | 0.90 | MAPT (0.41) | TSHRRAB9ALMNACA12CA1 | |
| SCHEMBL22394632 | 0.90 | MAPT (0.41) | TSHRRAB9ALMNACA12CA1 | |
| SCHEMBL8481716 | 0.90 | LMNA (0.43) | TSHRMRGPRX4RAB9AMAPK1LMNA | |
| SCHEMBL28471177 | 0.83 | PTGS1 (0.41) | MRGPRX4L3MBTL1RXRAPLA2G4BSRD5A2 | |
| SCHEMBL8478789 | 0.80 | EGFR (0.42) | TSHRMRGPRX4RAB9AMAPK1LMNA | |
| SCHEMBL22394631 | 0.80 | TSHR (0.48) | TSHRMRGPRX4RAB9AMAPK1LMNA | |
| SCHEMBL4630972 | 0.79 | EGFR (0.41) | TSHRRAB9ALMNACA12CA1 | |
| SCHEMBL22394682 | 0.74 | DPP4 (0.39) | RAB9AMAPK1LMNAHTTL3MBTL1 | |
| SCHEMBL6564723 | 0.73 | TSHR (0.77) | TSHRMRGPRX4RAB9AMAPK1LMNA | |
| SCHEMBL18044477 | 0.73 | SMN1; SMN2 (0.50) | MRGPRX4RAB9ALMNAL3MBTL1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111801322-B | Kinase inhibitors for the treatment of central and peripheral nervous system disorders | 迈阿密大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-111801322-A | Kinase inhibitors for the treatment of central and peripheral nervous system disorders | 迈阿密大学 | 2020-10-20 | — | — | CN | disclosed |