Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.72 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.72 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.72 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.72 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.72 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.72 |
| ▸ | P2RY14 | Q15391 | 7/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879099 | 0.89 | KCNH2 (0.66) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2844075 | 0.88 | KCNH2 (0.58) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846637 | 0.86 | KCNH2 (0.64) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2852677 | 0.86 | KCNH2 (0.62) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL24913685 | 0.84 | KCNH2 (1.00) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2847511 | 0.84 | KCNH2 (1.00) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846664 | 0.84 | KCNH2 (1.00) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2844400 | 0.80 | KCNH2 (0.72) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846217 | 0.80 | PSEN1 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846733 | 0.80 | KCNH2 (0.61) | KCNH2PTGS1PTGS2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | disclosed |