Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078864 | 0.87 | NPC1 (0.48) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL28314210 | 0.86 | EGFR (0.47) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL9416888 | 0.85 | EGFR (0.47) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL20922052 | 0.84 | MAPK14 (0.50) | EGFRMAPK14NPC1RAB9AKDR | |
| SCHEMBL21479384 | 0.83 | EGFR (0.44) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL4112548 | 0.83 | EGFR (0.66) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL21479387 | 0.81 | MAPK14 (0.47) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL23975356 | 0.78 | EGFR (0.36) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL9893035 | 0.77 | EGFR (0.51) | EGFRMAPK14SMN1; SMN2TDP1NPC1 | |
| SCHEMBL1015351 | 0.77 | RAF1 (0.50) | EGFRMAPK14NPC1RAB9AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12365685-B2 | Substituted fused aromatic ring derivative, composition and use thereof | SHENZHEN TARGETRX, INC. (CN) | 2025-07-22 | — | — | US | disclosed |
| US-20220098204-A1 | SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF | SHENZHEN TARGETRX, INC. (CN) | 2022-03-31 | — | — | US | disclosed |
| CN-111574521-A | Substituted aromatic fused ring derivatives, compositions and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2020-08-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220098204-A1 | SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF | BRAF, ALK, TYRO3 | EGFR 211/4885MAPK14 69/4885SMN1; SMN2 3191/4885 |
| US-12365685-B2 | Substituted fused aromatic ring derivative, composition and use thereof | BRAF, ALK, TYRO3 | EGFR 211/4885MAPK14 69/4885SMN1; SMN2 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.