Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225814 | 0.83 | SMN1; SMN2 (0.63) | GAAMAPTGFERALDH1A1NPC1 | |
| SCHEMBL789578 | 0.80 | GAA (0.50) | KIF11GAAMAPTGFERPEPD | |
| SCHEMBL4281427 | 0.80 | MAPT (0.70) | KIF11GAAMAPTGFERPEPD | |
| SCHEMBL28299722 | 0.80 | PTPN1 (0.70) | MAPTNPC1PTPN1MEN1KMT2A | |
| SCHEMBL2225726 | 0.77 | MKNK1 (0.50) | GAAMAPTALDH1A1NPC1LMNA | |
| SCHEMBL1510062 | 0.77 | CYP1A1 (0.54) | MAPTALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL4802418 | 0.76 | MEN1 (0.66) | GAAMAPTALDH1A1NPC1MEN1 | |
| SCHEMBL27806488 | 0.76 | RAB9A (0.52) | MAPTALDH1A1NPC1LMNAHTT | |
| SCHEMBL17200847 | 0.75 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2ATAAR1 | |
| SCHEMBL27320197 | 0.75 | GAA (0.44) | KIF11GAAMAPTGFERPEPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111699189-A | Modulators of beta-3 adrenergic receptors useful for the treatment or prevention of heart failure and disorders associated therewith | 艾尼纳制药公司 | 2020-09-22 | — | — | CN | disclosed |