Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | RBP4 | P02753 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2350768 | 0.88 | HRH4 (0.78) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL29944207 | 0.86 | HRH4 (0.76) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2345954 | 0.86 | HRH4 (0.76) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL1553345 | 0.85 | HRH4 (0.72) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL29699763 | 0.85 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL2679610 | 0.85 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL3253717 | 0.84 | POLB (1.00) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL22615176 | 0.84 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL9410801 | 0.84 | HRH4 (0.74) | HRH4HRH3POLBSMN1; SMN2AKR1C3 | |
| SCHEMBL604932 | 0.84 | HRH4 (1.00) | HRH4HRH3POLBSMN1; SMN2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |